CpgA

• Description: GTPase, activity stimulated by ribosomes, may be involved in ribosome maturation
  
  

Gene name	cpgA
Synonyms	yloQ
Essential	no
Product	GTPase
Function	ribosome assembly, coordination of peptidoglycan deposition in the cell wall
Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism
MW, pI	33 kDa, 4.743
Gene length, protein length	894 bp, 298 aa
Immediate neighbours	prkC, rpe
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU15780

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

cell wall/ other, translation, GTP-binding proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: engC GTPase domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on Ser/ Thr by PrkC, dephosphorylated by PrpC PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1T9H

• UniProt: O34530

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:
  • prpC-prkC-cpgA PubMed
  • cpgA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Tony Wilkinson, York University, U.K. homepage

References

Reviews

Robert A Britton
Role of GTPases in bacterial ribosome assembly.
Annu Rev Microbiol: 2009, 63;155-76
[PubMed:19575570] [WorldCat.org] [DOI] (I p)