PyrH

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  • Description: uridylate kinase

Gene name pyrH
Synonyms smbA
Essential no
Product uridylate kinase
Function pyrimidine biosynthesis
Metabolic function and regulation of this protein in SubtiPathways:
Pyrimidines, Nucleotides (regulation)
MW, pI 25 kDa, 5.101
Gene length, protein length 720 bp, 240 aa
Immediate neighbours tsf, frr
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PyrH context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU16510

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + UMP = ADP + UDP (according to Swiss-Prot)
  • Protein family: UMP kinase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure: 2JJX (from Bacillus anthracis, 42% identity, 64% similarity) PubMed
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References