MciZ

• Description: FtsZ inhibition peptide
  
  

Gene name	mciZ
Synonyms
Essential	no
Product	FtsZ inhibition peptide
Function	inhibits GTPase activity of FtsZ and Z ring formation during sporulation
MW, pI	4.8 kDa, y.yy
Gene length, protein length	120 bp, 40 aa
Immediate neighbours	nudF, yqkF
Gene sequence (+200bp)	Protein sequence
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag:

Database entries

• DBTBS entry: no entry

• SubtiList entry: no entry

Additional information

This gene was only recently identified. PubMed

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: inhibits GTPase activity of FtsZ and Z ring formation during sporulation PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: MciZ-FtsZ PubMed

• Localization:

Database entries

• Structure:

• Swiss prot entry:

• KEGG entry: no entry

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor: SigE PubMed

• Regulation:
  • expressed early during sporulation in the mother cell (SigE) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

David W Adams, Jeff Errington
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
Nat Rev Microbiol: 2009, 7(9);642-53
[PubMed:19680248] [WorldCat.org] [DOI] (I p)

Original Publications

Aaron A Handler, Joo Eun Lim, Richard Losick
Peptide inhibitor of cytokinesis during sporulation in Bacillus subtilis.
Mol Microbiol: 2008, 68(3);588-99
[PubMed:18284588] [WorldCat.org] [DOI] (I p)