Difference between revisions of "PbuG"
| Line 93: | Line 93: | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** repressed in the presence of purine nucleotides ([[PurR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/11591660 PubMed] | ||
** repressed by hypoxanthine and guanine, [[PurR]]-independent, ([[G-box]])[http://www.ncbi.nlm.nih.gov/sites/entrez/12923093 PubMed] | ** repressed by hypoxanthine and guanine, [[PurR]]-independent, ([[G-box]])[http://www.ncbi.nlm.nih.gov/sites/entrez/12923093 PubMed] | ||
** repressed in the presence of adenine or adenosine([[PurR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/2536750 PubMed] | ** repressed in the presence of adenine or adenosine([[PurR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/2536750 PubMed] | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[PurR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/11591660 PubMed] | ||
** [[PurR]]: transcription repression (molecular inducer: PRPP) [http://www.ncbi.nlm.nih.gov/sites/entrez/2536750 PubMed] | ** [[PurR]]: transcription repression (molecular inducer: PRPP) [http://www.ncbi.nlm.nih.gov/sites/entrez/2536750 PubMed] | ||
**[[G-box]]: transcription termination/ antitermination ([[riboswitch]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12923093 PubMed] | **[[G-box]]: transcription termination/ antitermination ([[riboswitch]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12923093 PubMed] | ||
Revision as of 17:10, 11 June 2009
- Description: hypoxanthin/ guanine permease
| Gene name | pbuG |
| Synonyms | yebB |
| Essential | no |
| Product | hypoxanthin/ guanine permease |
| Function | hypoxanthine and guanine uptake |
| MW, pI | 46 kDa, 8.808 |
| Gene length, protein length | 1320 bp, 440 aa |
| Immediate neighbours | guaA, yebC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU06370
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s): PbuO
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: membrane PubMed
Database entries
- Structure: 2EEW (the pbuG riboswitch, U47c mutant, bound to hypoxanthine)
- Swiss prot entry:
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: pbuG
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
- Hahne et al. (2008) From complementarity to comprehensiveness - targeting the membrane proteome of growing Bacillus subtilis by divergent approaches. Proteomics 8: 4123-4136 PubMed
- Johansen et al. (2003) Definition of a second Bacillus subtilis pur regulon comprising the pur and xpt-pbuX operons plus pbuG, nupG (yxjA), and pbuE (ydhL). J. Bacteriol. 185: 5200-5209. PubMed
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
