YvrHb

• Description: two-component response regulator
  
  

Gene name	yvrHb
Synonyms
Essential	no
Product	two-component response regulator
Function	regulation cell surface maintenance
MW, pI	26.6 kDa, 5.23
Gene length, protein length	714 bp, 237 amino acids
Immediate neighbours	yvrHa, yvrG
Gene sequence (+200bp)	Protein sequence
Genetic context

The gene

Basic information

• Coordinates (CDS):

Phenotypes of a mutant

unusual autolysis and higher susceptibility to cell envelope antibiotics (bacitracin, aztreonam, cefepime, fosfomycin) PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: no entry

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: transcription activator PubMed

• Protein family: OmpR family

• Paralogous protein(s):

The YvrHb regulon

subject to positive control: dltA-dltB-dltC-dltD-dltE, sigX-rsiX, sunA, sunT-bdbA-yolJ-bdbB, wapA-yxxG, wprA, yvrI-yvrHa PubMed

subject to negative control: lytA-lytB-lytC PubMed

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation (Asp) by YvrG PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions: YvrG-YvrHb PubMed

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• Swiss prot entry: P94504

• KEGG entry: no entry

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Serizawa M, Kodama K, Yamamoto H, Kobayashi K, Ogasawara N, Sekiguchi J. (2005) Functional analysis of the YvrGHb two-component system of Bacillus subtilis: identification of the regulated genes by DNA microarray and northern blot analyses. Biosci. Biotechnol. Biochem. 69: 2155-2169. PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed