Difference between revisions of "Sandbox"

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−
* '''Description:''' UDP-N-acetylglucosamine 1-carboxyvinyltransferase <br/><br/>
+
* '''Description:''' D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Gene name'''
 
|style="background:#ABCDEF;" align="center"|'''Gene name'''
−
|''murAA''
+
|''dltD''
 
|-
 
|-
−
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''murA ''
+
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ipa-2r ''
 
|-
 
|-
−
|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
+
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
 
|-
 
|-
−
|style="background:#ABCDEF;" align="center"| '''Product''' || UDP-N-acetylglucosamine 1-carboxyvinyltransferase
+
|style="background:#ABCDEF;" align="center"| '''Product''' || D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain
 
|-
 
|-
−
|style="background:#ABCDEF;" align="center"|'''Function''' || peptidoglycan (cell wall) biosynthesis
+
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of teichoic acid
 +
 
 +
acid (D-alanine transfer from undecaprenol-P to
 +
 
 +
the poly(glycerophosphate) chain of LTA)
 
|-
 
|-
−
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 46 kDa, 5.45  
+
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 44 kDa, 9.858  
 
|-
 
|-
−
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length'''  Arne mag Tintenfisch
+
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length'''  Arne mag seine mueffelnden Fuesse
−
|| 1308 bp, 436 aa  
+
|| 1176 bp, 392 aa  
 
|-
 
|-
−
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[spoIID]]'', ''[[ywmB]]''
+
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dltC]]'', ''[[dltE]]''
 
|-
 
|-
−
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/murAA_nucleotide.txt    Gene sequence      (+200bp)  ]'''  
+
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/dltD_nucleotide.txt    Gene sequence      (+200bp)  ]'''  
−
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/murAA_protein.txt Protein sequence]'''
+
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/dltD_protein.txt Protein sequence]'''
 
|-
 
|-
−
|colspan="2" | '''Genetic context''' <br/> [[Image:murAA_context.gif]]
+
|colspan="2" | '''Genetic context''' <br/> [[Image:dltD_context.gif]]
 
|-
 
|-
 
|}
 
|}
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===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
−
 
−
essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
 
  
 
=== Database entries ===
 
=== Database entries ===
  
−
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/murAA.html]
+
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/dltABCDE.html]
  
−
* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11955]
+
* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10548]
  
 
=== Additional information===
 
=== Additional information===
Line 88: Line 90:
  
 
=== Additional information===
 
=== Additional information===
−
 
−
MurAA is subject to [[ClpC]]-[[ClpP]]-dependent degradation  [http://www.ncbi.nlm.nih.gov/sites/entrez/14763982 PubMed]
 
  
 
=Expression and regulation=
 
=Expression and regulation=
  
−
* '''Operon:'''  
+
* '''Operon:''' ''[[dltA]]-[[dltB]]-[[dltC]]-[[dltD]]-[[dltE]]''
  
−
* '''Sigma factor:'''  
+
* '''Sigma factor:''' [[SigD]], [[SigX]]
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
  
−
* '''Regulatory mechanism:'''  
+
* '''Regulatory mechanism:''' activated by [[YvrHb]]  [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed]
  
−
* '''Additional information:'''  
+
* '''Additional information:'''
  
 
=Biological materials =
 
=Biological materials =
Line 123: Line 123:
 
=References=
 
=References=
  
−
# Kock H, Gerth U, Hecker M. (2004) MurAA, catalysing the first committed step in peptidoglycan biosynthesis, is a target of Clp-dependent proteolysis in Bacillus subtilis. Mol Microbiol, 51:1087-1102.  [http://www.ncbi.nlm.nih.gov/sites/entrez/14763982 PubMed]
 
 
# Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]
 
# Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]

Revision as of 15:25, 18 March 2009

  • Description: D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain

Gene name dltD
Synonyms ipa-2r
Essential no
Product D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain
Function biosynthesis of teichoic acid

acid (D-alanine transfer from undecaprenol-P to

the poly(glycerophosphate) chain of LTA)

MW, pI 44 kDa, 9.858
Gene length, protein length Arne mag seine mueffelnden Fuesse 1176 bp, 392 aa
Immediate neighbours dltC, dltE
Gene sequence (+200bp) Protein sequence
Genetic context
DltD context.gif



The gene

Basic information

  • Coordinates:

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • Swiss prot entry:
  • KEGG entry:
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
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