Difference between revisions of "Metabolism of signalling nucleotides"
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|Related= | |Related= | ||
* [[DAC domain]] | * [[DAC domain]] | ||
| + | * [[EAL domain]] | ||
| + | * [[GGDEF domain]] | ||
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===Protein potentially involved in c-di-GMP metabolism and signalling=== | ===Protein potentially involved in c-di-GMP metabolism and signalling=== | ||
| − | ==== Proteins containing a GGDEF domain (potential diguanylate cyclases) ==== | + | ==== Proteins containing a [[GGDEF domain]] (potential diguanylate cyclases) ==== |
* [[DgcK]], has cyclase activity | * [[DgcK]], has cyclase activity | ||
| − | * [[DgcW]], has cyclase activity, contains both a GGDEF and an EAL domain | + | * [[DgcW]], has cyclase activity, contains both a GGDEF and an [[EAL domain]] |
* [[DgcP]], has cyclase activity | * [[DgcP]], has cyclase activity | ||
| − | * [[YdaK]], no activity, | + | * [[YdaK]], no activity, degenerate [[GGDEF domain]] |
| − | * [[GdpP]], no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), | + | * [[GdpP]], no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), degenerate GGDEF domain |
| − | ==== Proteins containing an EAL domain (potential c-di-GMP phosphodiesterases) ==== | + | ==== Proteins containing an [[EAL domain]] (potential c-di-GMP phosphodiesterases) ==== |
* [[PdeH]], has phosphodiesterase activity | * [[PdeH]], has phosphodiesterase activity | ||
* [[YkuI]], no phosphodiesterase activity | * [[YkuI]], no phosphodiesterase activity | ||
| − | * [[DgcW]], phosphodiesterase activity not demonstrated, contains both a GGDEF and an EAL domain | + | * [[DgcW]], phosphodiesterase activity not demonstrated, contains both a GGDEF and an [[EAL domain]] |
=== Targets of signalling nucleotides === | === Targets of signalling nucleotides === | ||
Revision as of 12:12, 5 July 2016
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| Neighbouring categories | |
| Related categories | |
Contents
- 1 Genes in this functional category
- 2 Important original publications
- 3 Important reviews
- 4 Back to categories
Genes in this functional category
ppGpp synthesis and degradation
c-di-AMP synthesis
Control of c-di-AMP synthesis
Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well PubMed
c-di-AMP degradation
Protein potentially involved in c-di-GMP metabolism and signalling
Proteins containing a GGDEF domain (potential diguanylate cyclases)
- DgcK, has cyclase activity
- DgcW, has cyclase activity, contains both a GGDEF and an EAL domain
- DgcP, has cyclase activity
- YdaK, no activity, degenerate GGDEF domain
- GdpP, no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), degenerate GGDEF domain
Proteins containing an EAL domain (potential c-di-GMP phosphodiesterases)
- PdeH, has phosphodiesterase activity
- YkuI, no phosphodiesterase activity
- DgcW, phosphodiesterase activity not demonstrated, contains both a GGDEF and an EAL domain
Targets of signalling nucleotides
- c-di-GMP targets
- DgrA (contains a PilZ domain)
Important original publications
Important reviews
Erin B Purcell, Rita Tamayo
Cyclic diguanylate signaling in Gram-positive bacteria.
FEMS Microbiol Rev: 2016, 40(5);753-73
[PubMed:27354347]
[WorldCat.org]
[DOI]
(I p)
TuAnh Ngoc Huynh, Joshua J Woodward
Too much of a good thing: regulated depletion of c-di-AMP in the bacterial cytoplasm.
Curr Opin Microbiol: 2016, 30;22-29
[PubMed:26773214]
[WorldCat.org]
[DOI]
(I p)
Fabian M Commichau, Achim Dickmanns, Jan Gundlach, Ralf Ficner, Jörg Stülke
A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP.
Mol Microbiol: 2015, 97(2);189-204
[PubMed:25869574]
[WorldCat.org]
[DOI]
(I p)
Kuanqing Liu, Alycia N Bittner, Jue D Wang
Diversity in (p)ppGpp metabolism and effectors.
Curr Opin Microbiol: 2015, 24;72-9
[PubMed:25636134]
[WorldCat.org]
[DOI]
(I p)
Rebecca M Corrigan, Angelika Gründling
Cyclic di-AMP: another second messenger enters the fray.
Nat Rev Microbiol: 2013, 11(8);513-24
[PubMed:23812326]
[WorldCat.org]
[DOI]
(I p)
Dimpy Kalia, Gökçe Merey, Shizuka Nakayama, Yue Zheng, Jie Zhou, Yiling Luo, Min Guo, Benjamin T Roembke, Herman O Sintim
Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis.
Chem Soc Rev: 2013, 42(1);305-41
[PubMed:23023210]
[WorldCat.org]
[DOI]
(I p)
Mark Gomelsky
cAMP, c-di-GMP, c-di-AMP and now cGMP: bacteria use them all!
Mol Microbiol: 2011, 79(3);562-5
[PubMed:21255104]
[WorldCat.org]
[DOI]
(I p)
Tilman Schirmer, Urs Jenal
Structural and mechanistic determinants of c-di-GMP signalling.
Nat Rev Microbiol: 2009, 7(10);724-35
[PubMed:19756011]
[WorldCat.org]
[DOI]
(I p)
Regine Hengge
Principles of c-di-GMP signalling in bacteria.
Nat Rev Microbiol: 2009, 7(4);263-73
[PubMed:19287449]
[WorldCat.org]
[DOI]
(I p)
Ute Römling
Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea.
Sci Signal: 2008, 1(33);pe39
[PubMed:18714086]
[WorldCat.org]
[DOI]
(I e)
Peggy A Cotter, Scott Stibitz
c-di-GMP-mediated regulation of virulence and biofilm formation.
Curr Opin Microbiol: 2007, 10(1);17-23
[PubMed:17208514]
[WorldCat.org]
[DOI]
(P p)
Ute Römling, Mark Gomelsky, Michael Y Galperin
C-di-GMP: the dawning of a novel bacterial signalling system.
Mol Microbiol: 2005, 57(3);629-39
[PubMed:16045609]
[WorldCat.org]
[DOI]
(P p)
