Difference between revisions of "BceB"
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| − | * '''Description:''' [[ABC transporter]] (permease) for the export of bacitracin, plectasin, mersacidin and actagardine <br/><br/> | + | * '''Description:''' [[ABC transporter]] (permease) for the export of bacitracin, plectasin, mersacidin and actagardine, sensory component of the Bce regulatory & detoxification system <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| + | ** binds bacitracin, K<sup>D</sup>: 60 nM {{PubMed|25118291}} | ||
| + | ** inhibits [[BceS]] autophosphorylation activity in the absence of bacitracin {{PubMed|25118291}} | ||
* '''Protein family:''' ABC-4 integral membrane protein family (according to Swiss-Prot) | * '''Protein family:''' ABC-4 integral membrane protein family (according to Swiss-Prot) | ||
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* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| − | ** [[BceA]]-[[BceB]] {{PubMed|23687272}} | + | ** [[BceA]]-[[BceB]] {{PubMed|25118291,23687272}} |
| − | ** [[BceB]]-[[BceS]] {{PubMed|23687272,21283517}} | + | ** [[BceB]]-[[BceS]], in the absence of bacitracin {{PubMed|25118291,23687272,21283517}} |
* '''[[Localization]]:''' cell membrane (according to Swiss-Prot) | * '''[[Localization]]:''' cell membrane (according to Swiss-Prot) | ||
| Line 140: | Line 142: | ||
=References= | =References= | ||
| − | <pubmed>18394148,17905982,12890034,14651641,10092453, 14612242 21283517, 20606066 21078927 23687272 24806199</pubmed> | + | <pubmed>18394148,17905982,12890034,14651641,10092453, 14612242 21283517, 20606066 21078927 23687272 25118291,24806199</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:00, 26 April 2015
- Description: ABC transporter (permease) for the export of bacitracin, plectasin, mersacidin and actagardine, sensory component of the Bce regulatory & detoxification system
| Gene name | bceB |
| Synonyms | ytsD |
| Essential | no |
| Product | bacitracin ABC transporter (permease) |
| Function | export of toxic peptides |
| Gene expression levels in SubtiExpress: bceB | |
| Interactions involving this protein in SubtInteract: BceB | |
| MW, pI | 72 kDa, 9.79 |
| Gene length, protein length | 1938 bp, 646 aa |
| Immediate neighbours | yttA, bceA |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
ABC transporters, resistance against toxins/ antibiotics, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU30370
Phenotypes of a mutant
Database entries
- BsubCyc: BSU30370
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ABC-4 integral membrane protein family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- the activity of the BceA-BceB ABC transporter is inhibited by heptaprenyl pyrophosphate which accumulates in a ytpB mutant PubMed
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- BsubCyc: BSU30370
- Structure:
- UniProt: O34741
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
