Difference between revisions of "GdpP"
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
| − | {{SubtiWiki category|[[metabolism of signalling nucleotides]]}} | + | {{SubtiWiki category|[[metabolism of signalling nucleotides]]}}, |
| + | {{SubtiWiki category|[[membrane proteins]]}} | ||
| + | |||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
* inactivation of ''[[gdpP]]'' strongly restores beta-lactam resistance in a ''[[sigM]]'' mutant {{PubMed|22211522}} | * inactivation of ''[[gdpP]]'' strongly restores beta-lactam resistance in a ''[[sigM]]'' mutant {{PubMed|22211522}} | ||
| + | |||
=== Database entries === | === Database entries === | ||
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU40510&redirect=T BSU40510] | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU40510&redirect=T BSU40510] | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
| − | ** N- | + | ** two transmembrane domains at the N-terminus |
| + | ** a domain that shares minimum sequence homology with Heme-binding [[PAS domain|Per-ARNT-Sim (PAS) domains]] (80 aa) {{PubMed|21257773}} | ||
** degenerate GGDEF domain (aa 173 - 301) {{PubMed|22211522}} | ** degenerate GGDEF domain (aa 173 - 301) {{PubMed|22211522}} | ||
** DHH/ DHHA1 phosphodiesterase domain {{PubMed|22211522}} | ** DHH/ DHHA1 phosphodiesterase domain {{PubMed|22211522}} | ||
Revision as of 14:34, 25 February 2015
- Description: cyclic di-AMP phosphodiesterase
| Gene name | gdpP |
| Synonyms | yybT |
| Essential | no |
| Product | c-di-AMP phosphodiesterase |
| Function | control of sporulation initiation, cell wall homeostasis |
| Gene expression levels in SubtiExpress: gdpP | |
| Metabolic function and regulation of this protein in SubtiPathways: GdpP | |
| MW, pI | 74 kDa, 4.865 |
| Gene length, protein length | 1977 bp, 659 aa |
| Immediate neighbours | rplI, yybS |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
metabolism of signalling nucleotides, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU40510
Phenotypes of a mutant
Database entries
- BsubCyc: BSU40510
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- cyclic dinucleotide phosphodiesterase, hydrolysis of di-cyclic AMP PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- two transmembrane domains at the N-terminus
- a domain that shares minimum sequence homology with Heme-binding Per-ARNT-Sim (PAS) domains (80 aa) PubMed
- degenerate GGDEF domain (aa 173 - 301) PubMed
- DHH/ DHHA1 phosphodiesterase domain PubMed
- Modification:
- Cofactor(s): b-type heme with 1:1 stoichiometry PubMed
- Effectors of protein activity:
Database entries
- BsubCyc: BSU40510
- UniProt: P37484
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Regulatory mechanism:
Biological materials
- Mutant:
- GP998 (gdpP::spc), available in Jörg Stülke's lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
GdpP homologs in other organisms
