Difference between revisions of "Tmk"

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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 636 bp, 212 aa  
 
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 636 bp, 212 aa  
 
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yaaO]]'', ''[[yaaQ]]''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yaaO]]'', ''[[darA]]''
 
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU00280 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU00280 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU00280 DNA_with_flanks]
 
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU00280 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU00280 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU00280 DNA_with_flanks]
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= [[Categories]] containing this gene/protein =
 
= [[Categories]] containing this gene/protein =

Revision as of 12:57, 10 November 2014

  • Description: thymidylate kinase

Gene name tmk
Synonyms yaaP
Essential yes PubMed
Product thymidylate kinase
Function TTP biosynthesis
Gene expression levels in SubtiExpress: tmk
Metabolic function and regulation of this protein in SubtiPathways:
tmk
MW, pI 23 kDa, 4.866
Gene length, protein length 636 bp, 212 aa
Immediate neighbours yaaO, darA
Sequences Protein DNA DNA_with_flanks
Genetic context
Tmk context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Tmk expression.png















Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU00280

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + dTMP = ADP + dTDP (according to Swiss-Prot)
  • Protein family: thymidylate kinase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2CCK (from Staphylococcus aureus, 53% identity, 74% similarity) PubMed
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References