ndoA

ndoA
168

RNase EndoA, MazF family toxin, UACAU-specific mRNA interferase

Locus
BSU_04660
Molecular weight
12.84 kDa
Isoelectric point
4.89
Protein length
116 aaSequenceBlast
Gene length
351 bpSequenceBlast
Function
unknown
Product
mRNA interferase
Essential
no
Synonyms
ndoA, ydcE, mazF
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2337 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
518,943  519,293
The protein
Catalyzed reaction/ biological activity
specifically cleaves a five-base sequence, UACAU PubMed
Protein family
PemK/MazF family (single member, according to UniProt)
Structure
1NE8 (PDB) PubMed
4MDX (PDB) (NdoA-RNA) PubMed
4ME7 (PDB) (NdoA-NdoAI complex) PubMed
P96622 (AlphaFold)
Effectors of protein activity
the activity is inhibited by the interaction with NdoAI PubMed
Expression and Regulation
Operons
Genes
ndoAI-ndoA
Description
PubMed
Additional information
An ncRNA is predicted for 'ndoA' PubMed
Open in new tab

ndoAI→ndoA

2025-04-04 09:46:23

ghost

80

7f8a7dc2f7eaf781e947a6a63979c438df7e04e3

5DFE68AF98CACE6494FDB04249DEF62EF29E68F8

Genes
alr-ndoAI-ndoA
Description
PubMed
Open in new tab

alr→ndoA

2025-04-04 09:47:10

Jstuelk

89

91b7fa89916159e2bc7894e263572f1eeb4a5554

F1ED0F7D4D8E54352AA236431B9C138B1FC5ADBA

Biological materials
Mutant
BKE04660 (ndoA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATCGCCGCGTTTCACAATCA,  downstream forward: _UP4_TAGACATATTTGCAGGTTGC
BKK04660 (ndoA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATCGCCGCGTTTCACAATCA,  downstream forward: _UP4_TAGACATATTTGCAGGTTGC
References
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2E5A557E417CB355331CC0555D46A79793EB90B3

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Time of last update: 2025-04-06 02:56:52

Author of last update: Jstuelk