fabHA
168

beta-ketoacyl-acyl carrier protein synthase III, principal condensing enzyme responsible for the initiation of fatty acid synthesis in non-stressed B. subtilis cells

Locus

BSU_11330

Molecular weight

33.58 kDa

Isoelectric point

5.05

Protein length

312 aaSequenceBlast

Gene length

939 bpSequenceBlast

Function

fatty acid biosynthesis

Product

beta-ketoacyl-acyl carrier protein synthase III

Essential

E.C.

2.3.1.180

Synonyms

fabHA, yjaX

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0332 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,208,222 1,209,160

Phenotypes of a mutant

significant increase in the proportion of straight-chain fatty acids with a concomitant increase in 31:0-carbon phosphatidylethanolamine species PubMed

The protein

Catalyzed reaction/ biological activity

acetyl-CoA + H⁺ + malonyl-[ACP] --> 3-oxobutanoyl-[ACP] + CO₂ + CoA (according to UniProt)

Protein family

thiolase-like superfamily (according to UniProt)

Structure

8VD9 (PDB) PubMed

8VDA (PDB) (complex with CoA) PubMed

O34746 (AlphaFold)

Paralogous protein(s)

FabHB, one of the two proteins has to be present for viability PubMed

Localization