RecQ

• Description: ATP-dependent DNA helicase
  
  

Gene name	recQ
Synonyms	recS, ypbC
Essential	no
Product	ATP-dependent DNA helicase
Function	replication reactivation pathway
Gene expression levels in SubtiExpress: recQ
MW, pI	56 kDa, 6.228
Gene length, protein length	1488 bp, 496 aa
Immediate neighbours	ypbD, ypbB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination, membrane proteins

The gene

Basic information

• Locus tag: BSU23020

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: RecQ subfamily (according to Swiss-Prot)

• Paralogous protein(s): YocI

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • SsbA-RecQ according to PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P50729

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: recQ PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A893 (no resistance), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Justin S Lenhart, Jeremy W Schroeder, Brian W Walsh, Lyle A Simmons
DNA repair and genome maintenance in Bacillus subtilis.
Microbiol Mol Biol Rev: 2012, 76(3);530-64
[PubMed:22933559] [WorldCat.org] [DOI] (I p)

Kara A Bernstein, Serge Gangloff, Rodney Rothstein
The RecQ DNA helicases in DNA repair.
Annu Rev Genet: 2010, 44;393-417
[PubMed:21047263] [WorldCat.org] [DOI] (I p)

Leonard Wu, Ian D Hickson
RecQ helicases and cellular responses to DNA damage.
Mutat Res: 2002, 509(1-2);35-47
[PubMed:12427530] [WorldCat.org] [DOI] (P p)

Original publications

François Lecointe, Céline Sérèna, Marion Velten, Audrey Costes, Stephen McGovern, Jean-Christophe Meile, Jeffrey Errington, S Dusko Ehrlich, Philippe Noirot, Patrice Polard
Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks.
EMBO J: 2007, 26(19);4239-51
[PubMed:17853894] [WorldCat.org] [DOI] (P p)