YkuT

• Description: mechanosensitive channel, similar to MscS, general stress protein
  
  

Gene name	ykuT
Synonyms
Essential	no
Product	mechanosensitive channel, similar to MscS
Function	resistance to osmotic downshock
Gene expression levels in SubtiExpress: ykuT
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	29 kDa, 5.65
Gene length, protein length	801 bp, 267 aa
Immediate neighbours	ykuS, ykuU
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

general stress proteins (controlled by SigB), coping with hypo-osmotic stress, membrane proteins

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU14210

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane PubMed

Database entries

• Structure:

• UniProt: O34897

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: ykuT PubMed

• Sigma factor: SigB PubMed

• Regulation: induced by stress (SigB) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A960 ( ykuT::cat), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Erhard Bremer, University of Marburg, Germany homepage

References

Reviews

Ian R Booth, Paul Blount
The MscS and MscL families of mechanosensitive channels act as microbial emergency release valves.
J Bacteriol: 2012, 194(18);4802-9
[PubMed:22685280] [WorldCat.org] [DOI] (I p)

Christopher D Pivetti, Ming-Ren Yen, Samantha Miller, Wolfgang Busch, Yi-Hsiung Tseng, Ian R Booth, Milton H Saier
Two families of mechanosensitive channel proteins.
Microbiol Mol Biol Rev: 2003, 67(1);66-85, table of contents
[PubMed:12626684] [WorldCat.org] [DOI] (P p)