MdtP

• Description: multidrug-efflux transporter
  
  

Gene name	mdtP
Synonyms	yusP
Essential	no
Product	multidrug-efflux transporter
Function	multidrug resistance
Gene expression levels in SubtiExpress: mdtP
MW, pI	57 kDa, 9.836
Gene length, protein length	1623 bp, 541 aa
Immediate neighbours	mdtR, yusQ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context

Categories containing this gene/protein

transporters/ other, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

MdtR regulon

The gene

Basic information

• Locus tag:

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: EmrB family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot), membrane associated PubMed

Database entries

• Structure:

• UniProt: O32182

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: mdtR-mdtP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism: repression by MdtR PubMed

• Additional information:

Biological materials

• Mutant: BP70 (spc) available in Stülke lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Ji-Yun Kim, Takashi Inaoka, Kazutaka Hirooka, Hiroshi Matsuoka, Makiko Murata, Reiko Ohki, Yoshikazu Adachi, Yasutaro Fujita, Kozo Ochi
Identification and characterization of a novel multidrug resistance operon, mdtRP (yusOP), of Bacillus subtilis.
J Bacteriol: 2009, 191(10);3273-81
[PubMed:19286808] [WorldCat.org] [DOI] (I p)

Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711] [WorldCat.org] [DOI] (I p)