Difference between revisions of "HprT"
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[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 12:21, 21 September 2012
- Description: hypoxanthine phosphoribosyltransferase
| Gene name | hprT |
| Synonyms | |
| Essential | yes PubMed |
| Product | hypoxanthine phosphoribosyltransferase |
| Function | purine salvage and interconversion |
| Gene expression levels in SubtiExpress: hprT | |
| Metabolic function and regulation of this protein in SubtiPathways: Purine salvage, Purine synthesis, Nucleotides (regulation) | |
| MW, pI | 20 kDa, 4.603 |
| Gene length, protein length | 540 bp, 180 aa |
| Immediate neighbours | tilS, ftsH |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of nucleotides, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00680
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
- Protein family: purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´PubMed
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 1J7J (from Salmonella typhimurium, 51% identity, 73% similarity)
- UniProt: P37472
- KEGG entry: [2]
- E.C. number: 2.4.2.8
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
