PhrF

• Description: response regulator aspartate phosphatase (RapF) regulator, antagonizes the RapF-ComA interaction
  
  

Gene name	phrF
Synonyms	ywhI
Essential	no
Product	phosphatase (RapF) regulator
Function	control of ComA activity
Gene expression levels in SubtiExpress: phrF
Interactions involving this protein in SubtInteract: PhrF
MW, pI	4 kDa, 10.237
Gene length, protein length	117 bp, 39 aa
Immediate neighbours	rapF, ywhH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

genetic competence, transcription factors and their control, quorum sensing, short peptides

This gene is a member of the following regulons

ComA regulon, SigH regulon

The gene

Basic information

• Locus tag: BSU37470

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: binds to RapF, this results in the inability of RapF to interact with ComA PubMed

• Protein family: phr family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • RapF-PhrF PubMed

• Localization:

Database entries

• Structure:

• UniProt: P71001

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • rapF-phrF PubMed
  • phrF PubMed

• Expression browser: phrF PubMed

• Sigma factor:
  • phrF: SigH PubMed

• Regulation:
  • PhrF accumulates at high cell density

• Regulatory mechanism:
  • ComA: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: