YycH

• Description: negative effector of WalK, controls cell wall metabolism
  
  

Gene name	yycH
Synonyms
Essential	no
Product	negative effector of WalK
Function	control of cell wall metabolism
Interactions involving this protein in SubtInteract: YycH
MW, pI	52 kDa, 5.589
Gene length, protein length	1365 bp, 455 aa
Immediate neighbours	yycI, walK
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall/ other, transcription factors and their control, membrane proteins

The gene

Basic information

• Locus tag: BSU40390

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • YycH-YycI PubMed
  • WalK-YycH PubMed

• Localization: cell membrane (according to Swiss-Prot), spotty close to the membrane PubMed

Database entries

• Structure: 2FGT

• UniProt: Q794W0

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: walR-walK-yycH-yycI-walJ-yyxA PubMed

• Expression browser: yycH PubMed

• Sigma factor:

• Regulation: expressed during vegetative growth, repressed during stationary phase PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Tatsuya Fukushima, Isako Furihata, Robyn Emmins, Richard A Daniel, James A Hoch, Hendrik Szurmant
A role for the essential YycG sensor histidine kinase in sensing cell division.
Mol Microbiol: 2011, 79(2);503-22
[PubMed:21219466] [WorldCat.org] [DOI] (I p)

Hendrik Szurmant, Lintao Bu, Charles L Brooks, James A Hoch
An essential sensor histidine kinase controlled by transmembrane helix interactions with its auxiliary proteins.
Proc Natl Acad Sci U S A: 2008, 105(15);5891-6
[PubMed:18408157] [WorldCat.org] [DOI] (I p)

Patrick D McLaughlin, Benjamin G Bobay, Erin J Regel, Richele J Thompson, James A Hoch, John Cavanagh
Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition.
FEBS Lett: 2007, 581(7);1425-9
[PubMed:17350627] [WorldCat.org] [DOI] (P p)

Hendrik Szurmant, Michael A Mohan, P Michael Imus, James A Hoch
YycH and YycI interact to regulate the essential YycFG two-component system in Bacillus subtilis.
J Bacteriol: 2007, 189(8);3280-9
[PubMed:17307850] [WorldCat.org] [DOI] (P p)

Hendrik Szurmant, Haiyan Zhao, Michael A Mohan, James A Hoch, Kottayil I Varughese
The crystal structure of YycH involved in the regulation of the essential YycFG two-component system in Bacillus subtilis reveals a novel tertiary structure.
Protein Sci: 2006, 15(4);929-34
[PubMed:16600972] [WorldCat.org] [DOI] (P p)

Hendrik Szurmant, Kristine Nelson, Eun-Ja Kim, Marta Perego, James A Hoch
YycH regulates the activity of the essential YycFG two-component system in Bacillus subtilis.
J Bacteriol: 2005, 187(15);5419-26
[PubMed:16030236] [WorldCat.org] [DOI] (P p)

C Fabret, J A Hoch
A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy.
J Bacteriol: 1998, 180(23);6375-83
[PubMed:9829949] [WorldCat.org] [DOI] (P p)