TruA

• Description: pseudouridylate synthase I, universally conserved protein
  
  

Gene name	truA
Synonyms	ybaH
Essential	no
Product	pseudouridylate synthase I
Function	tRNA modification
MW, pI	27 kDa, 6.652
Gene length, protein length	741 bp, 247 aa
Immediate neighbours	ybaF, rplM
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

translation, universally conserved proteins

This gene is a member of the following regulons

stringent response

The gene

Basic information

• Locus tag: BSU01480

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: tRNA uridine = tRNA pseudouridine (according to Swiss-Prot)

• Protein family: tRNA pseudouridine synthase truA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P70973

• KEGG entry: [2]

• E.C. number:

Additional information

universally conserved protein

Expression and regulation

• Operon:

• Expression browser: truA PubMed

• Sigma factor:

• Regulation:
  • RelA dependent downregulation (Class I) during stringent response PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Christine Eymann, Georg Homuth, Christian Scharf, Michael Hecker
Bacillus subtilis functional genomics: global characterization of the stringent response by proteome and transcriptome analysis.
J Bacteriol: 2002, 184(9);2500-20
[PubMed:11948165] [WorldCat.org] [DOI] (P p)