Difference between revisions of "Apt"
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* '''Operon:''' ''[[yrvE]]-[[apt]]'' {{PubMed|15241682}} | * '''Operon:''' ''[[yrvE]]-[[apt]]'' {{PubMed|15241682}} | ||
| − | * '''[ | + | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=apt_2822901_2823413_-1 apt] {{PubMed|22383849}} |
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| + | * '''Sigma factor:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
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* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 14:11, 16 April 2012
- Description: adenine phosphoribosyltransferase, universally conserved protein
| Gene name | apt |
| Synonyms | |
| Essential | no |
| Product | adenine phosphoribosyltransferase |
| Function | purine salvage and interconversion |
| Metabolic function and regulation of this protein in SubtiPathways: Purine salvage, Purine synthesis, Nucleotides (regulation) | |
| MW, pI | 18 kDa, 4.701 |
| Gene length, protein length | 510 bp, 170 aa |
| Immediate neighbours | relA, yrvE |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of nucleotides, universally conserved proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU27610
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
- Protein family: purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 2DY0 (from Escherichia coli k12, 56% identity, 66% similarity)
- UniProt: O34443
- KEGG entry: [3]
- E.C. number: 2.4.2.7
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
M Nickel, G Homuth, C Böhnisch, U Mäder, T Schweder
Cold induction of the Bacillus subtilis bkd operon is mediated by increased mRNA stability.
Mol Genet Genomics: 2004, 272(1);98-107
[PubMed:15241682]
[WorldCat.org]
[DOI]
(P p)
H H Saxild, P Nygaard
Genetic and physiological characterization of Bacillus subtilis mutants resistant to purine analogs.
J Bacteriol: 1987, 169(7);2977-83
[PubMed:3110131]
[WorldCat.org]
[DOI]
(P p)
