BpsA

• Description: type III polyketide synthase
  
  

Gene name	bpsA
Synonyms	bcsA
Essential	no
Product	type III polyketide synthase
Function	polyketide synthesis
MW, pI	40 kDa, 7.958
Gene length, protein length	1095 bp, 365 aa
Immediate neighbours	bpsB, pbuX
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds, membrane proteins

The gene

Basic information

• Locus tag: BSU22050

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: synthesis of triketide pyrones from long-chain fatty acyl CoA thioesters as starter substrates and malonyl-CoA as an extender substrate PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P54157

• KEGG entry: [2]

• E.C. number: 2.3.1.74

Expression and regulation

• Operon: bpsA-bpsB PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Chiaki Nakano, Hiroki Ozawa, Genki Akanuma, Nobutaka Funa, Sueharu Horinouchi
Biosynthesis of aliphatic polyketides by type III polyketide synthase and methyltransferase in Bacillus subtilis.
J Bacteriol: 2009, 191(15);4916-23
[PubMed:19465653] [WorldCat.org] [DOI] (I p)