Maf

• Description: cell division inhibitor in competent cells, blocks septation during the escape from competence, required for the stability of ComGA
  
  

Gene name	maf
Synonyms
Essential	no
Product	cell division inhibitor
Function	cell division control
Interactions involving this protein in SubtInteract: Maf
MW, pI	21 kDa, 5.711
Gene length, protein length	567 bp, 189 aa
Immediate neighbours	radC, spoIIB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

cell division

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

• Locus tag: BSU28050

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: maf family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): binds phosphorylated compounds (UTP, IMP, IDP, GDP and others) in in vitro experiments

• Effectors of protein activity:

• Interactions:
  • forms dimers PubMed
  • Maf-DivIVA PubMed
  • Maf-FtsW PubMed
  • Maf-ComGA PubMed

• Localization:
  • near the poles of competent cells PubMed

Database entries

• Structure: 1EX2

• UniProt: Q02169

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:
  • expressed when cells enter the compentent state (ComK) PubMed
  • expression is reduced in a SigV mutant PubMed

• Regulatory mechanism:
  • ComK: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

PubMed

Original publications

Additional publications: PubMed