YxbA

• Description: putative D-aspartate ligase
  
  

Gene name	yxbA
Synonyms	yxaO, aslA
Essential	no
Product	putative D-aspartate ligase
Function	unknown
Metabolic function and regulation of this protein in SubtiPathways: Asp, Asn
MW, pI	10 kDa, 4.433
Gene length, protein length	267 bp, 89 aa
Immediate neighbours	yxbB, yxnB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU39900

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

poorly characterized/ putative enzymes

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P46325

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • yxbB-yxbA-yxnB-asnH-yxaM PubMed
  • yxbB-yxbA-yxnB PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by glucose (8-fold) PubMed
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • repressed during logrithmic growth (AbrB) PubMed

• Regulatory mechanism:
  • CodY: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:
  • the tricistronic yxbB-yxbA-yxnB transcript is extremely stable, and stability is mediated by a 5'-proximal long sequence triplication preceding the yxbB open reading frame PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: