Difference between revisions of "MntC"
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=Expression and regulation= | =Expression and regulation= | ||
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* '''Operon:''' ''[[mntA]]-[[mntB]]-[[mntC]]-[[mntD]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed] | * '''Operon:''' ''[[mntA]]-[[mntB]]-[[mntC]]-[[mntD]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed] | ||
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
| − | * '''Regulation:''' | + | * '''Regulation:''' |
| − | ** activated at low Mn(II) concentrations (MntR) [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed] | + | ** activated at low Mn(II) concentrations ([[MntR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed] |
| − | * '''Regulatory mechanism:''' | + | * '''Regulatory mechanism:''' |
** [[MntR]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed] | ** [[MntR]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed] | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 20:44, 19 December 2009
- Description: manganese ABC transporter (membrane protein)
| Gene name | mntC |
| Synonyms | ytgC |
| Essential | no |
| Product | manganese ABC transporter (membrane protein))) |
| Function | manganese uptake |
| Metabolic function and regulation of this protein in SubtiPathways: Stress | |
| MW, pI | 47 kDa, 9.354 |
| Gene length, protein length | 1305 bp, 435 aa |
| Immediate neighbours | mntD, mntB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU30750
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ABC-3 integral membrane protein family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O35024
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
Emmanuel Guedon, Charles M Moore, Qiang Que, Tao Wang, Rick W Ye, John D Helmann
The global transcriptional response of Bacillus subtilis to manganese involves the MntR, Fur, TnrA and sigmaB regulons.
Mol Microbiol: 2003, 49(6);1477-91
[PubMed:12950915]
[WorldCat.org]
[DOI]
(P p)
Q Que, J D Helmann
Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins.
Mol Microbiol: 2000, 35(6);1454-68
[PubMed:10760146]
[WorldCat.org]
[DOI]
(P p)
Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453]
[WorldCat.org]
[DOI]
(P p)
