Difference between revisions of "MurD"
| Line 94: | Line 94: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' [[murE]]-[[mraY]]-[[murD]]-[[spoVE]]-[[murG]]-[[murB]]-[[divIB]]-[[ylxW]]-[[ylxX]]-[[sbp]] | + | * '''Operon:''' ''[[murE]]-[[mraY]]-[[murD]]-[[spoVE]]-[[murG]]-[[murB]]-[[divIB]]-[[ylxW]]-[[ylxX]]-[[sbp]]'' {{PubMed|1391053}} |
| − | * '''[[Sigma factor]]:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** expressed during vegatative growth {{PubMed|1391053}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| Line 124: | Line 125: | ||
=References= | =References= | ||
| − | <pubmed>8436954,18063720,, </pubmed> | + | <pubmed>8436954,18063720,1391053, </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 11:55, 10 October 2009
- Description: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
| Gene name | murD |
| Synonyms | |
| Essential | yes PubMed |
| Product | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase |
| Function | peptidoglycan precursor biosynthesis |
| Metabolic function and regulation of this protein in SubtiPathways: Cell wall | |
| MW, pI | 49 kDa, 5.566 |
| Gene length, protein length | 1353 bp, 451 aa |
| Immediate neighbours | mraY, spoVE |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU15200
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (according to Swiss-Prot)
- Protein family: murCDEF family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: Q03522
- KEGG entry: [3]
- E.C. number: 6.3.2.9
Additional information
Expression and regulation
- Regulation:
- expressed during vegatative growth PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Jean van Heijenoort
Lipid intermediates in the biosynthesis of bacterial peptidoglycan.
Microbiol Mol Biol Rev: 2007, 71(4);620-35
[PubMed:18063720]
[WorldCat.org]
[DOI]
(P p)
R A Daniel, J Errington
DNA sequence of the murE-murD region of Bacillus subtilis 168.
J Gen Microbiol: 1993, 139(2);361-70
[PubMed:8436954]
[WorldCat.org]
[DOI]
(P p)
A O Henriques, H de Lencastre, P J Piggot
A Bacillus subtilis morphogene cluster that includes spoVE is homologous to the mra region of Escherichia coli.
Biochimie: 1992, 74(7-8);735-48
[PubMed:1391053]
[WorldCat.org]
[DOI]
(P p)
