MntD

• Description: manganese ABC transporter
  
  

Gene name	mntD
Synonyms	ytgD
Essential	no
Product	manganese ABC transporter
Function	manganese uptake
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	30 kDa, 6.308
Gene length, protein length	885 bp, 295 aa
Immediate neighbours	ythC, mntC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU30740

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ABC-3 integral membrane protein family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• Swiss prot entry: O34500

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mntA-mntB-mntC-mntD PubMed

• Sigma factor:

• Regulation: repressed by Mn(2+) (MntR) PubMed
  • activated at low Mn(II) concentrations (MntR) PubMed

• Regulatory mechanism: MntR: transcription repression PubMed
  • MntR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

References

1. Que Q, Helmann JD. (2000) Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins. Mol Microbiol. Mar;35(6): 1454-68. PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed