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| − | * '''Description:''' methionine synthase <br/><br/>
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| − | {| align="right" border="1" cellpadding="2"
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| − | |-
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| − | |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| − | |''metE''
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| − | |-
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| − | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''metC ''
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| − | |-
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| − | |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| − | |-
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| − | |style="background:#ABCDEF;" align="center"| '''Product''' || methionine synthase
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| − | |-
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| − | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of methionine
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| − | |-
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| − | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 86 kDa, 4.839
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| − | |-
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| − | |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2286 bp, 762 aa
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| − | |-
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| − | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[guaD]]'', ''[[ispA]]''
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| − | |-
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| − | |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB13175]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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| − | |-
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| − | |colspan="2" | '''Genetic context''' <br/> [[Image:metE_context.gif]]
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| − | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| − | |-
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| − | |}
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| − | __TOC__
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| − | <br/><br/>
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| − |
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| − | =The gene=
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| − |
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| − | === Basic information ===
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| − | * '''Coordinates:'''
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| − |
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| − | ===Phenotypes of a mutant ===
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| − |
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| − | === Database entries ===
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| − | * '''DBTBS entry:''' no entry
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| − | * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12616]
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| − |
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| − | === Additional information===
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| − |
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| − | =The protein=
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| − |
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| − | === Basic information/ Evolution ===
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| − | * '''Catalyzed reaction/ biological activity:'''
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| − | * '''Protein family:'''
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| − | * '''Paralogous protein(s):'''
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| − |
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| − | === Extended information on the protein ===
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| − |
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| − | * '''Kinetic information:'''
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| − | * '''Domains:'''
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| − | * '''Modification:''' phosphorylated on ser/ thr/ tyr [http://www.ncbi.nlm.nih.gov/pubmed/17726680 PubMed]
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| − | * '''Cofactor(s):'''
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| − | * '''Effectors of protein activity:'''
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| − | * '''Interactions:'''
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| − | * '''Localization:'''
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| − |
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| − | === Database entries ===
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| − | * '''Structure:'''
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| − | * '''Swiss prot entry:'''
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| − | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU13180]
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| − | * '''E.C. number:'''
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| − |
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| − | === Additional information===
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| − | :* subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=+17981983 PubMed]
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| − | =Expression and regulation=
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| − | * '''Operon:'''
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| − | * '''[[Sigma factor]]:'''
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| − | * '''Regulation:''' repressed by casamino acids [http://www.ncbi.nlm.nih.gov/pubmed/12107147 PubMed]
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| − | * '''Regulatory mechanism:''' [[S-box Element]]
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| − | * '''Additional information:''' subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=+17981983 PubMed]
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| − |
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| − | =Biological materials =
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| − | * '''Mutant:'''
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| − | * '''Expression vector:'''
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| − |
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| − | * '''lacZ fusion:'''
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| − | * '''GFP fusion:'''
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| − | * '''two-hybrid system:'''
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| − | * '''Antibody:'''
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| − | =Labs working on this gene/protein=
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| − | =Your additional remarks=
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| − | =References=
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| − | # Eymann et al. (2007) Dynamics of protein phosphorylation on Ser/Thr/Tyr in ''Bacillus subtilis''. ''Proteomics'' '''7:''' 3509-3526. [http://www.ncbi.nlm.nih.gov/pubmed/17726680 PubMed]
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| − | # Mäder et al. (2002) Transcriptome and Proteome Analysis of ''Bacillus subtilis'' Gene Expression Modulated by Amino Acid Availability. ''J. Bacteriol'' '''184:''' 1844288-4295 [http://www.ncbi.nlm.nih.gov/pubmed/12107147 PubMed]
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| − | # Gerth et al. (2008) Clp-dependent proteolysis down-regulates central metabolic pathways in glucose-starved Bacillus subtilis. J Bacteriol 190:321-331 [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=+17981983 PubMed]
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| − | # Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]
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