Difference between revisions of "Main Page"

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<big>'''Paper of the month: May 2015'''</big>  
 
<big>'''Paper of the month: May 2015'''</big>  
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* In ''B. subtilis'', ribosomal stalling is used to regulate the expression of the membrane protein biogenesis factor [[YidC2]]. This is achieved by stalling during [[translation]] of the [[MifM]] leader peptide. In the absence of structures of Gram-positive bacterial ribosomes, a molecular basis for species-specific stalling has remained unclear. [http://www.ncbi.nlm.nih.gov/pubmed/25903689 Sohmen et al.] have determined the structure of the [[MifM]]-stalled 70S [[ribosome]] and have unraveled a network of interactions between [[MifM]] and the ribosomal tunnel, which induces translational arrest. Complementary genetic analyses identify a single amino acid within [[ribosomal protein]] [[rplV|L22]] that dictates the species specificity of the stalling event.  
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* The precise quantification of the dynamic changes in metabolite concentrations is a major challenge in metabolomics. Two new studies make use of the combination of metablite-sensitive riboswitches with an ''in vitro'' selected Spinach aptamer, which binds a pro-fluorescent, cell-permeable small molecule mimic of the GFP chromophore. Fluorescence can then be determined as a measure of the concentration of the metabolite that binds the riboswitch. The present studies use this approach for the essential second messenger c-di-AMP as well as for S-adenosyl-methionine and guanine.
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** '''Relevant ''Subti''Wiki pages:''' [[translation]], [[ribosome]], ''[[yidC2]]'', [[MifM]], [[rplV|L22]]
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** '''Relevant ''Subti''Wiki pages:''' [[riboswitch]], [[metabolism]], [[methods]]
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<pubmed> 25903689</pubmed>
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<pubmed25964329 25965978</pubmed>
 
* [[Previous papers of the month]]
 
* [[Previous papers of the month]]
  

Revision as of 08:49, 4 June 2015

Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!

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Contact: General Microbiology, University of Göttingen, send mail


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New: Subtiwiki is now on Facebook - please give it a +1!



Now online: A new description of SubtiWiki and its acompanying modules in the 2014 Database issue of Nucleic Acids Research

Raphael H Michna, Fabian M Commichau, Dominik Tödter, Christopher P Zschiedrich, Jörg Stülke
SubtiWiki-a database for the model organism Bacillus subtilis that links pathway, interaction and expression information.
Nucleic Acids Res: 2014, 42(Database issue);D692-8
[PubMed:24178028] [WorldCat.org] [DOI] (I p)



Paper of the month: May 2015

  • The precise quantification of the dynamic changes in metabolite concentrations is a major challenge in metabolomics. Two new studies make use of the combination of metablite-sensitive riboswitches with an in vitro selected Spinach aptamer, which binds a pro-fluorescent, cell-permeable small molecule mimic of the GFP chromophore. Fluorescence can then be determined as a measure of the concentration of the metabolite that binds the riboswitch. The present studies use this approach for the essential second messenger c-di-AMP as well as for S-adenosyl-methionine and guanine.

<pubmed25964329 25965978</pubmed>


New procedure for account creation:

  • Due to massive spam attacks, we had to change our policy for the creation of accounts. If you want to create an account, just send me a mail. We will create the account for you as quickly as possible, then you can change your password. This does not affect existing accounts, which remain active.
  • Please remember that all members of the Bacillus community are invited to create accounts and to contribute to SubtiWiki!



News in SubtiWiki:

  • August 2014: The first mobile application for SubtiWiki is now available for users of Android phones: Go for SubtiWiki in Google Play! IPhone users, please be patient! You will be served next! Click here to install!
  • April 2013: SubtiWiki uses a new, faster Mediawiki platform! The times for page access are significantly reduced. Enjoy!
  • March 2013: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
  • October 2012: the essential genes have been categorized
  • September 2012: 300 mutant strains available at the BGSC were added to the corresponding gene pages
  • August 2012: SubtiExpress, the new compagnon of SubtiWiki devoted to gene expression is online! Try it out!
  • April 2012: Links for expression data under 104 different conditions (based on Nicolas et al., 2012) have been added to the expression section of the individual gene pages
  • April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
  • December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways



Genes (examples) Additional pages
spo0A SubtiPathways
glnA SubtInteract
rny SubtiExpress
psdA Regulons
pckA methods
dnaA metabolism
rnpA categories
sigB genome-wide analyses
ptkA list of plasmids
mreC labs working on Bacillus
ccpA the people behind SubtiWiki
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Publications describing SubtiWiki and SubtiPathways:







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