Difference between revisions of "Main Page"

From SubtiWiki
Jump to: navigation, search
Line 21: Line 21:
  
 
<br/>
 
<br/>
<big>'''Paper of the month: June 2014'''</big>  
+
<big>'''Paper of the month: July 2014'''</big>  
* [[Transcription]] by [[RNA polymerase]] is interrupted by pauses that play diverse regulatory roles. However, the determinants of pauses ''in vivo'' and their distribution throughout the bacterial genome remain unknown. Using nascent transcript sequencing, [http://www.ncbi.nlm.nih.gov/pubmed/24789973 Larson et al.] identified a 16-nucleotide consensus pause sequence. The pauses result from [[RNA polymerase]]-nucleic acid interactions that inhibit next-nucleotide addition. The consensus sequence is enriched at [[translation]] start sites in Bacillus subtilis.  
+
* [[T-box]]es are regulatory mRNA elements which sense amino acid availability and control the expression of genes encoding aminoacyl-tRNA synthetases and biosynthetic enzymes. Sensing is thought to occur by the interaction of the uncharged tRNA with the T-box thus preventing the formation of a [[transcription]] terminator. It has however, not been known whether this regulation involves proteins. Now, [http://www.ncbi.nlm.nih.gov/pubmed/24954903 Zhang and Ferre-D'Amare] show that the ''B. subtilis'' ''[[glyQ]]-[[glyS]]'' [[T-box]] functions independently of any tRNA-binding protein. They demonstrate that the [[T-box]] detects the molecular volume of tRNA 3'-substituents..  
** '''Relevant ''Subti''Wiki pages:''' [[RNA polymerase]], [[transcription]], [[translation]]
+
** '''Relevant ''Subti''Wiki pages:''' [[T-box]], [[glyQ]]
<pubmed> 24789973 </pubmed>
+
<pubmed> 24954903 </pubmed>
* See a comment on this issue:
+
 
<pubmed> 24926002 </pubmed>
 
  
 
* [[Previous papers of the month]]
 
* [[Previous papers of the month]]

Revision as of 09:24, 4 July 2014

Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!

Start page small.png
Playground small.png
Wish List small.png


Contact: General Microbiology, University of Göttingen, send mail


Upcoming events:


New: Subtiwiki is now on Facebook - please give it a +1!



Now online: A new description of SubtiWiki and its acompanying modules in the 2014 Database issue of Nucleic Acids Research



Paper of the month: July 2014

  • T-boxes are regulatory mRNA elements which sense amino acid availability and control the expression of genes encoding aminoacyl-tRNA synthetases and biosynthetic enzymes. Sensing is thought to occur by the interaction of the uncharged tRNA with the T-box thus preventing the formation of a transcription terminator. It has however, not been known whether this regulation involves proteins. Now, Zhang and Ferre-D'Amare show that the B. subtilis glyQ-glyS T-box functions independently of any tRNA-binding protein. They demonstrate that the T-box detects the molecular volume of tRNA 3'-substituents..



New procedure for account creation:

  • Due to massive spam attacks, we had to change our policy for the creation of accounts. If you want to create an account, just send me a mail. We will create the account for you as quickly as possible, then you can change your password. This does not affect existing accounts, which remain active.
  • Please remember that all members of the Bacillus community are invited to create accounts and to contribute to SubtiWiki!



News in SubtiWiki:

  • April 2013: SubtiWiki uses a new, faster Mediawiki platform! The times for page access are significantly reduced. Enjoy!
  • March 2013: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
  • October 2012: the essential genes have been categorized
  • September 2012: 300 mutant strains available at the BGSC were added to the corresponding gene pages
  • August 2012: SubtiExpress, the new compagnon of SubtiWiki devoted to gene expression is online! Try it out!
  • April 2012: Links for expression data under 104 different conditions (based on Nicolas et al., 2012) have been added to the expression section of the individual gene pages
  • April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
  • December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways



Genes (examples) Additional pages
spo0A SubtiPathways
glnA SubtInteract
rny SubtiExpress
psdA Regulons
pckA methods
dnaA metabolism
rnpA categories
sigB genome-wide analyses
ptkA list of plasmids
mreC labs working on Bacillus
ccpA the people behind SubtiWiki
sr1 template


Publications describing SubtiWiki and SubtiPathways: