fadM

fadM
168

fatty acid degradation, similar to proline dehydrogenase

Locus
BSU_32850
Molecular weight
34.30 kDa
Isoelectric point
9.38
Protein length
302 aaSequenceBlast
Gene length
909 bpSequenceBlast
Function
fatty acid degradation
Product
unknown
Essential
no
Synonyms
fadM, yusM
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0506 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,372,740 → 3,373,648
The protein
Catalyzed reaction/ biological activity
quinone + L-proline --> (S)-1-pyrroline-5-carboxylate + quinol + H+ (according to UniProt)
Protein family
proline dehydrogenase family (with PutB, according to UniProt)
Cofactors
FAD (according to UniProt)
Structure
4H6Q (PDB) (from Deinococcus radiodurans, 48% identity) PubMed
O32179 (AlphaFold)
Paralogous protein(s)
PutB
Expression and Regulation
Operons
Genes
fadM-fadN-fadA-fadE
Description
PubMed
Regulation
''fadM'': induced by long-chain fatty acids (FadR) PubMed
Regulatory mechanism
FadR: repression, PubMed, in fadR regulon
SdpR: activation, PubMed, in sdpR regulon
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fadM→fadE

2025-03-16 11:32:37

ghost

101

9bfdfb93c4077983c0e3142e433ac74ae81a5d62

8E61A92B7F4E3CA1E4373E8AFCCD07598481ACA4

Biological materials
Mutant
MGNA-A598 (yusM::erm), available at the NBRP B. subtilis, Japan
BKE32850 (ΔfadM::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCCGACTCCCTCCCGCCG,  downstream forward: _UP4_TGAAAGCAGCCGTGGGAAGC
BKK32850 (ΔfadM::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCCGACTCCCTCCCGCCG,  downstream forward: _UP4_TGAAAGCAGCCGTGGGAAGC
References
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Time of last update: 2025-04-10 00:27:33

Author of last update: Melvin.boenninger