ctpA
168

carboxy-terminal processing protease, promotes DNA damage checkpoint recovery

Locus

BSU_19590

Molecular weight

50.98 kDa

Isoelectric point

8.86

Protein length

466 aaSequenceBlast

Gene length

1401 bpSequenceBlast

Function

unknown

Product

carboxy-terminal processing protease

Essential

Synonyms

ctpA, yzbD

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0793 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

2,131,902 2,133,302

Phenotypes of a mutant

deletion of CtpA and DdcP leads to accumulation of the checkpoint protein YneA PubMed

sensitivity to DNA damage PubMed

The protein

Catalyzed reaction/ biological activity

digestion of YneA PubMed

The enzyme shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala-|-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala (according to UniProt).

Protein family

Peptidase s41a family (together with CtpB, according to Uniprot)

Domains

signal peptide (aa 1 - 36) PubMed

PDZ domain (aa 96- 174) PubMed

S41 peptidase domain PubMed

peptidoglycan binding domain (C-terminal) PubMed

Structure

4C2D (PDB) (CtpB, 42% identity) PubMed

O34666 (AlphaFold)

Paralogous protein(s)

CtpB