Difference between revisions of "Main Page"

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<big>'''Paper of the month: April 2014'''</big>  
 
<big>'''Paper of the month: April 2014'''</big>  
* In a paper from the labs of [[Roberto Kolter]] and [[Richard Losick]] {{PubMed|22541437}} it was reported that ''B. subtilis'' synthesizes norspermidine and that this compound is involved in biofilm disassembly. Now, [http://www.ncbi.nlm.nih.gov/pubmed/24529384 Hobley et al.] from the lab of [[Nicola Stanley-Wall]] provide compelling evidence that ''B. subtilis'' does not produce norspermidine, that previous function annotations of a norspermidine biosynthetic pathway were made in error, and that norspermidine stimulates [[biofilm formation]].
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* [[DNA repair/ recombination|DNA repair and recombination]] involve the unwinding and digestion of the DNA duplex by the [[AddA]]-[[AddB]] from the broken end until they encounter a χ sequence, whereupon the proteins produce a 3′ single-stranded DNA tail onto which they initiate loading of the [[RecA]] protein. Now, two studies from the lab of [[Mark Dillingham]] address the structure of [[Add]]-[[AddB]] complexed to a χ sequence, and the effect of χ binding for processivity and ATP hydrolysis by [[AddA]]-[[AddB]].
 
* '''Relevant ''Subti''Wiki pages:''' [[Mark Dillingham]], [[DNA repair/ recombination]], [[AddA]], [[AddB]]
 
* '''Relevant ''Subti''Wiki pages:''' [[Mark Dillingham]], [[DNA repair/ recombination]], [[AddA]], [[AddB]]
 
<pubmed> 24682829 24670664 </pubmed>
 
<pubmed> 24682829 24670664 </pubmed>

Revision as of 17:49, 2 April 2014

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Paper of the month: April 2014

Neville S Gilhooly, Mark S Dillingham
Recombination hotspots attenuate the coupled ATPase and translocase activities of an AddAB-type helicase-nuclease.
Nucleic Acids Res: 2014, 42(9);5633-43
[PubMed:24682829] [WorldCat.org] [DOI] (I p)

Wojciech W Krajewski, Xin Fu, Martin Wilkinson, Nora B Cronin, Mark S Dillingham, Dale B Wigley
Structural basis for translocation by AddAB helicase-nuclease and its arrest at χ sites.
Nature: 2014, 508(7496);416-9
[PubMed:24670664] [WorldCat.org] [DOI] (I p)


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News in SubtiWiki:

  • April 2013: SubtiWiki uses a new, faster Mediawiki platform! The times for page access are significantly reduced. Enjoy!
  • March 2013: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
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  • April 2012: Links for expression data under 104 different conditions (based on Nicolas et al., 2012) have been added to the expression section of the individual gene pages
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