Difference between revisions of "ZapA"
| Line 53: | Line 53: | ||
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * a ''[[zapA]] [[ezrA]]'' double mutant forms filamentous cells {{PubMed|16420366}} | ||
| + | * a ''[[yvcL]] [[zapA]]'' double mutant grows poorly, and the cells are filamentous (due to a defect in Z ring assembly) {{PubMed|24097947}} | ||
| + | * the defects of the ''[[yvcL]] [[zapA]]'' double mutant can be suppressed by inactivation of either ''[[gtaB]]'', ''[[pgcA]]'', or ''[[ugtP]]'' {{PubMed|24097947}} | ||
=== Database entries === | === Database entries === | ||
| Line 61: | Line 64: | ||
=== Additional information=== | === Additional information=== | ||
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| − | |||
| − | |||
=The protein= | =The protein= | ||
| Line 79: | Line 79: | ||
* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| Line 142: | Line 142: | ||
==Original Publications== | ==Original Publications== | ||
| − | <pubmed>15288790,12368265,,18588879, 19429628 19843223 </pubmed> | + | <pubmed>15288790,12368265,16420366,18588879, 19429628 19843223 24097947</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 18:13, 21 December 2013
- Description: positive modulator of FtsZ Z ring assembly and stability
| Gene name | zapA |
| Synonyms | yshA |
| Essential | no |
| Product | Z-ring-associated protein |
| Function | control of Z-ring formation |
| Gene expression levels in SubtiExpress: zapA | |
| Interactions involving this protein in SubtInteract: ZapA | |
| MW, pI | 9 kDa, 7.17 |
| Gene length, protein length | 255 bp, 85 aa |
| Immediate neighbours | yshB, rnhC |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
cell division, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU28610
Phenotypes of a mutant
- a zapA ezrA double mutant forms filamentous cells PubMed
- a yvcL zapA double mutant grows poorly, and the cells are filamentous (due to a defect in Z ring assembly) PubMed
- the defects of the yvcL zapA double mutant can be suppressed by inactivation of either gtaB, pgcA, or ugtP PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: Type 2 subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P94542
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- constitutively expressed PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Erik Nico Trip, Jan-Willem Veening, Eric J Stewart, Jeff Errington, Dirk-Jan Scheffers
Balanced transcription of cell division genes in Bacillus subtilis as revealed by single cell analysis.
Environ Microbiol: 2013, 15(12);3196-209
[PubMed:23701187]
[WorldCat.org]
[DOI]
(I p)
Marc Bramkamp, Suey van Baarle
Division site selection in rod-shaped bacteria.
Curr Opin Microbiol: 2009, 12(6);683-8
[PubMed:19884039]
[WorldCat.org]
[DOI]
(I p)
David W Adams, Jeff Errington
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
Nat Rev Microbiol: 2009, 7(9);642-53
[PubMed:19680248]
[WorldCat.org]
[DOI]
(I p)
Original Publications
