SpoIIP

• Description: cell wall hydrolase with both amidase and endopeptidase activities, required for dissolution of the septal cell wall
  
  

Gene name	spoIIP
Synonyms
Essential	no
Product	cell wall hydrolase
Function	dissolution of the septal cell wall
Gene expression levels in SubtiExpress: spoIIP
Interactions involving this protein in SubtInteract: SpoIIP
MW, pI	44 kDa, 6.852
Gene length, protein length	1203 bp, 401 aa
Immediate neighbours	yqxA, gpr
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall/ other, sporulation proteins, membrane proteins

This gene is a member of the following regulons

SigE regulon, SigF regulon, Efp-dependent proteins

The gene

Basic information

• Locus tag: BSU25530

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • removes the stem peptides from the cell wall and cleaves the cross-links between them PubMed
  • required for proper localization of SpoIIQ (together with SpoIID) PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: activity is stimulated by interaction with SpoIID PubMed

• Interactions:
  • SpoIID-SpoIIP PubMed
  • SpoIIP-SpoIIM PubMed

• Localization: cell membrane PubMed

Database entries

• Structure:

• UniProt: P37968

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoIIP-yqxA PubMed, gpr-spoIIP PubMed

• Expression browser: spoIIP PubMed

• Sigma factor:
  • spoIIP: SigE PubMed
  • gpr:SigF PubMed

• Regulation: expressed early during sporulation (SigE,SigF) PubMed

• Regulatory mechanism:

• Additional information:
  • translation is likely to require Efp due to the presence of several consecutive proline residues PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: