Difference between revisions of "PurR"
| Line 1: | Line 1: | ||
| − | * '''Description:''' | + | * '''Description:''' transcription repressor of the pur operon <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 10: | Line 10: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || transcription repressor of the pur operon |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of purine biosynthesis |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 31 kDa, 5.771 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 31 kDa, 5.771 | ||
Revision as of 17:06, 16 March 2009
- Description: transcription repressor of the pur operon
| Gene name | purR |
| Synonyms | yabI |
| Essential | no |
| Product | transcription repressor of the pur operon |
| Function | regulation of purine biosynthesis |
| MW, pI | 31 kDa, 5.771 |
| Gene length, protein length | 855 bp, 285 aa |
| Immediate neighbours | ispE, yabJ |
| Gene sequence (+200bp) | Protein sequence |
Genetic context 
| |
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Biological activity: transcriptional repressor of purine biosynthetic operons
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: PRPP acts as inducer, binding results in release of PurR from the operator PubMed
- Interactions:
- Localization:
Database entries
- Swiss prot entry:
- KEGG entry:
- E.C. number:
Additional information
requires YabJ for in vivo activity
Expression and regulation
- Sigma factor:
- Regulation: negative autoregulation PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
- Weng et al. (1995) Identification of the Bacillus subtilis pur operon repressor. Proc. Natl. Acad. Sci. USA 92: 7455-7459. PubMed
- Weng & Zalkin (2000) Mutations in the Bacillus subtilis purine repressor that perturb PRPP effector function in vitro and in vivo.Currr. Microbiol. 41: 56-59. PubMed
- Sinha et al. (2003) The purine repressor of Bacillus subtilis: a novel combination of domains adapted for transcription regulation.J. Bacteriol. 185: 4087-4098. PubMed
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
