Ung

• Description: uracil-DNA glycosylase
  
  

Gene name	ung
Synonyms	ipa-57d, ywdG
Essential	no
Product	uracil-DNA glycosylase
Function	DNA repair
Gene expression levels in SubtiExpress: ung
Interactions involving this protein in SubtInteract: Ung
MW, pI	25 kDa, 8.782
Gene length, protein length	675 bp, 225 aa
Immediate neighbours	ywdH, ywdF
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination

The gene

Basic information

• Locus tag: BSU37970

Phenotypes of a mutant

• increased mutation rates PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: removes uracil preferentially from single-stranded DNA over double-stranded DNA, exhibiting higher preference for U:G than U:A mismatches PubMed

• Protein family: uracil-DNA glycosylase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • SsbA-Ung PubMed

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 3A7N (from Mycobacterium tuberculosis, 42% identity) PubMed

• UniProt: P39615

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ung PubMed

• Expression browser: ung PubMed

• Sigma factor:

• Regulation:
  • expressed throughout growth and staionary phase PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Justin S Lenhart, Jeremy W Schroeder, Brian W Walsh, Lyle A Simmons
DNA repair and genome maintenance in Bacillus subtilis.
Microbiol Mol Biol Rev: 2012, 76(3);530-64
[PubMed:22933559] [WorldCat.org] [DOI] (I p)