Difference between revisions of "ThyA"
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU17680&redirect=T BSU17680] | ||
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU17680&redirect=T BSU17680] | ||
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1B02 1B02] | * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1B02 1B02] | ||
Revision as of 13:49, 2 April 2014
- Description: thymidylate synthase A
| Gene name | thyA |
| Synonyms | |
| Essential | no |
| Product | thymidylate synthase A |
| Function | biosynthesis of thymidine nucleotides |
| Gene expression levels in SubtiExpress: thyA | |
| MW, pI | 32 kDa, 5.502 |
| Gene length, protein length | 837 bp, 279 aa |
| Immediate neighbours | ynzJ, yncM |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of nucleotides
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU17680
Phenotypes of a mutant
Database entries
- BsubCyc: BSU17680
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP (according to Swiss-Prot)
- Protein family: Bacterial-type thyA subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cytoplasm (according to Swiss-Prot)
Database entries
- BsubCyc: BSU17680
- Structure: 1B02
- UniProt: P42326
- KEGG entry: [2]
- E.C. number: 2.1.1.45
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
A Yazgan, G Ozcengiz, M A Marahiel
Tn10 insertional mutations of Bacillus subtilis that block the biosynthesis of bacilysin.
Biochim Biophys Acta: 2001, 1518(1-2);87-94
[PubMed:11267663]
[WorldCat.org]
[DOI]
(P p)
