Difference between revisions of "ChaA"
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{{SubtiWiki category|[[metal ion homeostasis (K, Na, Ca, Mg)]]}}, | {{SubtiWiki category|[[metal ion homeostasis (K, Na, Ca, Mg)]]}}, | ||
{{SubtiWiki category|[[sporulation proteins]]}}, | {{SubtiWiki category|[[sporulation proteins]]}}, | ||
| − | {{SubtiWiki category|[[general stress proteins (controlled by SigB)]]}} | + | {{SubtiWiki category|[[general stress proteins (controlled by SigB)]]}}, |
| + | {{SubtiWiki category|[[membrane proteins]]}} | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
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* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| + | ** forms a homotrimer {{PubMed|23798403}} | ||
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
| + | ** cell membrane {{PubMed|23798403}} | ||
=== Database entries === | === Database entries === | ||
| − | * '''Structure:''' | + | * '''Structure:''' [http://www.rcsb.org/pdb/explore/explore.do?structureId=4KJS 4KJS] {{PubMed|23798403}} |
* '''UniProt:''' [http://www.uniprot.org/uniprot/O34840 O34840] | * '''UniProt:''' [http://www.uniprot.org/uniprot/O34840 O34840] | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yfkE_865205_866260_1 chaA] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yfkE_865205_866260_1 chaA] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' [[SigG]], [[SigB]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19543710 PubMed] | + | * '''[[Sigma factor]]:''' [[SigG]], [[SigB]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19543710 PubMed] |
* '''Regulation:''' expressed in the forespore ([[SigG]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/19543710 PubMed] | * '''Regulation:''' expressed in the forespore ([[SigG]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/19543710 PubMed] | ||
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=References= | =References= | ||
| − | <pubmed>19543710 </pubmed> | + | <pubmed>19543710 23798403 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 08:42, 1 July 2013
- Description: H+/Ca2+ exchanger
| Gene name | chaA |
| Synonyms | yfkE |
| Essential | no |
| Product | calcium transport in/out via proton antiporter |
| Function | calcium uptake/ export |
| Gene expression levels in SubtiExpress: chaA | |
| MW, pI | 37 kDa, 5.206 |
| Gene length, protein length | 1053 bp, 351 aa |
| Immediate neighbours | yfkF, yfkD |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), sporulation proteins, general stress proteins (controlled by SigB), membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU07920
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- forms a homotrimer PubMed
- Localization:
- cell membrane PubMed
Database entries
- UniProt: O34840
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Mousheng Wu, Shuilong Tong, Sandro Waltersperger, Kay Diederichs, Meitian Wang, Lei Zheng
Crystal structure of Ca2+/H+ antiporter protein YfkE reveals the mechanisms of Ca2+ efflux and its pH regulation.
Proc Natl Acad Sci U S A: 2013, 110(28);11367-72
[PubMed:23798403]
[WorldCat.org]
[DOI]
(I p)
Makoto Fujisawa, Yuko Wada, Takahiro Tsuchiya, Masahiro Ito
Characterization of Bacillus subtilis YfkE (ChaA): a calcium-specific Ca2+/H+ antiporter of the CaCA family.
Arch Microbiol: 2009, 191(8);649-57
[PubMed:19543710]
[WorldCat.org]
[DOI]
(I p)
