Alr

Gene name	alr
Synonyms	dal, alrA
Essential	yes PubMed
Product	alanine racemase
Function	peptidoglycan biosynthesis
Gene expression levels in SubtiExpress: alr
MW, pI	43 kDa, 8.431
Gene length, protein length	1167 bp, 389 aa
Immediate neighbours	ydcC, ndoAI
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

The gene

Basic information

• Locus tag: BSU04640

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU04640

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: L-alanine = D-alanine (according to Swiss-Prot)

• Protein family: alanine racemase family (according to Swiss-Prot)

• Paralogous protein(s): YncD

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU04640

• Structure: 1L6G (with N-[5�-phosphopyridoxyl]-D-alanine, Geobacillus stearothermophilus), 1SFT (Geobacillus stearothermophilus)

• UniProt: P10725

• KEGG entry: [2]

• E.C. number: 5.1.1.1

Expression and regulation

• Operon:

• Expression browser: alr PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

M P Heaton, R B Johnston, T L Thompson
Controlled lysis of bacterial cells utilizing mutants with defective synthesis of D-alanine.
Can J Microbiol: 1988, 34(3);256-61
[PubMed:3138014] [WorldCat.org] [DOI] (P p)