Difference between revisions of "RecQ"

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Revision as of 13:47, 16 May 2013

  • Description: ATP-dependent DNA helicase

Gene name recQ
Synonyms recS, ypbC
Essential no
Product ATP-dependent DNA helicase
Function replication reactivation pathway
Gene expression levels in SubtiExpress: recQ
MW, pI 56 kDa, 6.228
Gene length, protein length 1488 bp, 496 aa
Immediate neighbours ypbD, ypbB
Sequences Protein DNA DNA_with_flanks
Genetic context
RecQ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
RecQ expression.png
























Categories containing this gene/protein

DNA repair/ recombination, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU23020

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: RecQ subfamily (according to Swiss-Prot)
  • Paralogous protein(s): YocI

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Kara A Bernstein, Serge Gangloff, Rodney Rothstein
The RecQ DNA helicases in DNA repair.
Annu Rev Genet: 2010, 44;393-417
[PubMed:21047263] [WorldCat.org] [DOI] (I p)

Leonard Wu, Ian D Hickson
RecQ helicases and cellular responses to DNA damage.
Mutat Res: 2002, 509(1-2);35-47
[PubMed:12427530] [WorldCat.org] [DOI] (P p)


Original Publications

François Lecointe, Céline Sérèna, Marion Velten, Audrey Costes, Stephen McGovern, Jean-Christophe Meile, Jeffrey Errington, S Dusko Ehrlich, Philippe Noirot, Patrice Polard
Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks.
EMBO J: 2007, 26(19);4239-51
[PubMed:17853894] [WorldCat.org] [DOI] (P p)

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