Difference between revisions of "CsaA"
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Revision as of 13:33, 16 May 2013
- Description: molecular chaperone involved in protein secretion
| Gene name | csaA |
| Synonyms | |
| Essential | no |
| Product | molecular chaperone |
| Function | protein secretion |
| Gene expression levels in SubtiExpress: csaA | |
| Interactions involving this protein in SubtInteract: CsaA | |
| Metabolic function and regulation of this protein in SubtiPathways: Protein secretion | |
| MW, pI | 11 kDa, 8.691 |
| Gene length, protein length | 330 bp, 110 aa |
| Immediate neighbours | bsrF, yobQ |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
protein secretion, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU19040
Phenotypes of a mutant
From unsuccessful trials to knock out the gene it was concluded that csaA apparently is essential. However, in a conditional mutant (Pspac-csaA), depletion of the gene product is not lethal. But secretion of some proteins including SdpC was reported to be affected unter such conditions.PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Secretion associated chaperone. Assumed functional analogue of E. coli SecB
- Protein family: FIG1 subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: CsaA contains a tRNA binding domain.
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure: 2NZO
- UniProt: P37584
- KEGG entry: [2]
- E.C. number:
Additional information
The functional entity of CsaA is the homodimer.
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant: Pspac-csaA PubMed
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
