Difference between revisions of "Fra"
| Line 28: | Line 28: | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
|- | |- | ||
| − | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ydhG_621847_622218_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:fra_expression.png|500px]] | + | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ydhG_621847_622218_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:fra_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU05750]] |
|- | |- | ||
|} | |} | ||
Revision as of 12:39, 16 May 2013
- Description: frataxin-like protein, required for the biosynthesis of iron-sulfur clusters
| Gene name | fra |
| Synonyms | ydhG |
| Essential | no |
| Product | frataxin-like protein |
| Function | intracellular iron channeling, biosynthesis of iron-sulfur clusters |
| Gene expression levels in SubtiExpress: fra | |
| Interactions involving this protein in SubtInteract: Fra | |
| MW, pI | 14 kDa, 5.377 |
| Gene length, protein length | 369 bp, 123 aa |
| Immediate neighbours | phoB, ydhH |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU05750
Phenotypes of a mutant
- severe growth phenotype associated with a broadly disturbed iron homeostasis PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transfers iron onto the B. subtilis SUF system (SufU-SufS) for iron-sulfur cluster biosynthesis PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): Fe(2+) is bound with high affinity PubMed
- Effectors of protein activity:
Database entries
- Structure: 2OC6
- UniProt: Q797E6
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant: available in Mohamed Marahiel's lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Wenbin Qi, J A Cowan
A structural and functional homolog supports a general role for frataxin in cellular iron chemistry.
Chem Commun (Camb): 2010, 46(5);719-21
[PubMed:20087498]
[WorldCat.org]
[DOI]
(I p)
