Difference between revisions of "MutM"

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* '''Description:''' formamidopyrimidine-DNA glycosidase <br/><br/>
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{| align="right" border="1" cellpadding="2"
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Gene name'''
 
|''mutM''
 
|-
 
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ytaE ''
 
|-
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
 
|-
 
|style="background:#ABCDEF;" align="center"| '''Product''' || formamidopyrimidine-DNA glycosidase
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair
 
|-
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU29080 mutM]
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 31 kDa, 8.889 
 
|-
 
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 834 bp, 278 aa
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ytaF]]'', ''[[polA]]''
 
|-
 
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU29080 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU29080 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU29080 Advanced_DNA]
 
|-
 
|colspan="2" | '''Genetic context''' <br/> [[Image:mutM_context.gif]]
 
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 
|-
 
|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mutM_2972329_2973159_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:mutM_expression.png|500px]]
 
|-
 
|}
 
 
 
__TOC__
 
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= [[Categories]] containing this gene/protein =
 
{{SubtiWiki category|[[DNA repair/ recombination]]}}
 
 
 
= This gene is a member of the following [[regulons]] =
 
 
 
 
 
=The gene=
 
 
 
=== Basic information ===
 
 
 
* '''Locus tag:''' BSU29080
 
 
 
===Phenotypes of a mutant ===
 
 
 
=== Database entries ===
 
 
 
* '''DBTBS entry:''' no entry
 
 
 
* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12628]
 
 
 
=== Additional information===
 
 
 
 
 
 
 
 
 
=The protein=
 
 
 
=== Basic information/ Evolution ===
 
 
 
* '''Catalyzed reaction/ biological activity:''' Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine (according to Swiss-Prot)
 
 
 
* '''Protein family:''' FPG family (according to Swiss-Prot)
 
 
 
* '''Paralogous protein(s):'''
 
 
 
=== Extended information on the protein ===
 
 
 
* '''Kinetic information:'''
 
 
 
* '''Domains:'''
 
 
 
* '''Modification:'''
 
 
 
* '''Cofactor(s):'''
 
 
 
* '''Effectors of protein activity:'''
 
 
 
* '''[[SubtInteract|Interactions]]:'''
 
 
 
* '''[[Localization]]:'''
 
** cytoplasm (according to Swiss-Prot)
 
 
 
=== Database entries ===
 
 
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2F5S 2F5S] (complex with oxoG:C, Geobacillus stearothermophilus)
 
 
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/O34403 O34403]
 
 
 
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU29080]
 
 
 
* '''E.C. number:''' [http://www.expasy.org/enzyme/3.2.2.23 3.2.2.23]
 
 
 
=== Additional information===
 
 
 
=Expression and regulation=
 
 
 
* '''Operon:'''
 
 
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mutM_2972329_2973159_-1 mutM] {{PubMed|22383849}}
 
 
 
* '''Sigma factor:'''
 
 
 
* '''Regulation:'''
 
 
 
* '''Regulatory mechanism:'''
 
 
 
* '''Additional information:'''
 
 
 
=Biological materials =
 
 
 
* '''Mutant:'''
 
 
 
* '''Expression vector:'''
 
       
 
* '''lacZ fusion:'''
 
 
 
* '''GFP fusion:'''
 
 
 
* '''two-hybrid system:'''
 
 
 
* '''Antibody:'''
 
 
 
=Labs working on this gene/protein=
 
 
 
=Your additional remarks=
 
 
 
=References=
 
<pubmed> 19011023 19889642 </pubmed>
 
[[Category:Protein-coding genes]]
 

Revision as of 18:59, 13 May 2013