Difference between revisions of "AlsR"
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of acetoin synthesis (''[[alsS]]-[[alsD]]'') | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of acetoin synthesis (''[[alsS]]-[[alsD]]'') | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU36020 alsR] |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]''' | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[alsS]]'', ''[[ywrK]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[alsS]]'', ''[[ywrK]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU36020 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU36020 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU36020 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:alsR_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:alsR_context.gif]] | ||
Revision as of 14:01, 13 May 2013
| Gene name | alsR |
| Synonyms | |
| Essential | no |
| Product | transcriptional activator(LysR family) |
| Function | regulation of acetoin synthesis (alsS-alsD) |
| Gene expression levels in SubtiExpress: alsR | |
| Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism | |
| MW, pI | 34 kDa, 7.288 |
| Gene length, protein length | 906 bp, 302 aa |
| Immediate neighbours | alsS, ywrK |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
carbon core metabolism, transcription factors and their control
This gene is a member of the following regulons
The AlsR regulon:
The gene
Basic information
- Locus tag: BSU36020
Phenotypes of a mutant
no acetoin production
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
- A mutation was found in this gene after evolution under relaxed selection for sporulation PubMed
- Inactivation of alsR, sigD and sigW increases competitive fitness of Bacillus subtilis under non-sporulating conditions PubMed
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: binds the promoter region of the alsS-alsD operon in the presence of acetate, activates transcription
- Protein family: LysR family of transcription factors
- Paralogous protein(s):
Extended information on the protein
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: Q04778
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Elisabeth Härtig, Braunschweig, Germany Homepage
Your additional remarks
References
Reviews
Elisabeth Härtig, Dieter Jahn
Regulation of the anaerobic metabolism in Bacillus subtilis.
Adv Microb Physiol: 2012, 61;195-216
[PubMed:23046954]
[WorldCat.org]
[DOI]
(I p)
Original publications
