Difference between revisions of "Metabolism of signalling nucleotides"
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===c-di-AMP synthesis=== | ===c-di-AMP synthesis=== | ||
* [[DisA]] | * [[DisA]] | ||
| − | * [[ | + | * [[CdaA]] |
| − | * [[ | + | * [[CdaS]] |
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| + | === Control of c-di-AMP synthesis === | ||
| + | * [[CdaR]] | ||
| + | |||
| + | Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well {{PubMed|23192352}} | ||
===c-di-AMP degradation=== | ===c-di-AMP degradation=== | ||
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==Important original publications== | ==Important original publications== | ||
| − | <pubmed>21566650 22981860 </pubmed> | + | <pubmed>21566650 22981860 23192352 </pubmed> |
==Important reviews== | ==Important reviews== | ||
<pubmed>21255104 16045609 17208514 19756011 19287449 18714086 23023210 </pubmed> | <pubmed>21255104 16045609 17208514 19756011 19287449 18714086 23023210 </pubmed> | ||
=Back to [[categories]]= | =Back to [[categories]]= | ||
Revision as of 11:53, 30 November 2012
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Contents
Genes in this functional category
ppGpp synthesis and degradation
c-di-AMP synthesis
Control of c-di-AMP synthesis
Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well PubMed
c-di-AMP degradation
c-di-GMP degradation (presence of an EAL domain)
c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)
Targets of signalling nucleotides
- c-di-GMP targets
- YpfA (contains a PilZ domain)
Important original publications
Important reviews
Dimpy Kalia, Gökçe Merey, Shizuka Nakayama, Yue Zheng, Jie Zhou, Yiling Luo, Min Guo, Benjamin T Roembke, Herman O Sintim
Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis.
Chem Soc Rev: 2013, 42(1);305-41
[PubMed:23023210]
[WorldCat.org]
[DOI]
(I p)
Mark Gomelsky
cAMP, c-di-GMP, c-di-AMP and now cGMP: bacteria use them all!
Mol Microbiol: 2011, 79(3);562-5
[PubMed:21255104]
[WorldCat.org]
[DOI]
(I p)
Tilman Schirmer, Urs Jenal
Structural and mechanistic determinants of c-di-GMP signalling.
Nat Rev Microbiol: 2009, 7(10);724-35
[PubMed:19756011]
[WorldCat.org]
[DOI]
(I p)
Regine Hengge
Principles of c-di-GMP signalling in bacteria.
Nat Rev Microbiol: 2009, 7(4);263-73
[PubMed:19287449]
[WorldCat.org]
[DOI]
(I p)
Ute Römling
Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea.
Sci Signal: 2008, 1(33);pe39
[PubMed:18714086]
[WorldCat.org]
[DOI]
(I e)
Peggy A Cotter, Scott Stibitz
c-di-GMP-mediated regulation of virulence and biofilm formation.
Curr Opin Microbiol: 2007, 10(1);17-23
[PubMed:17208514]
[WorldCat.org]
[DOI]
(P p)
Ute Römling, Mark Gomelsky, Michael Y Galperin
C-di-GMP: the dawning of a novel bacterial signalling system.
Mol Microbiol: 2005, 57(3);629-39
[PubMed:16045609]
[WorldCat.org]
[DOI]
(P p)
