Difference between revisions of "UppS"
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|style="background:#ABCDEF;" align="center"|'''Function''' || cell wall biosynthesis | |style="background:#ABCDEF;" align="center"|'''Function''' || cell wall biosynthesis | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU16530 uppS] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.408 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.408 | ||
| Line 22: | Line 22: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[frr]]'', ''[[cdsA]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[frr]]'', ''[[cdsA]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU16530 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU16530 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU16530 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:uppS_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:uppS_context.gif]] | ||
Revision as of 12:51, 13 May 2013
- Description: undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis
| Gene name | uppS |
| Synonyms | yluA |
| Essential | yes PubMed |
| Product | undecaprenyl pyrophosphate synthetase |
| Function | cell wall biosynthesis |
| Gene expression levels in SubtiExpress: uppS | |
| MW, pI | 29 kDa, 5.408 |
| Gene length, protein length | 780 bp, 260 aa |
| Immediate neighbours | frr, cdsA |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
cell wall synthesis, biosynthesis of lipids, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU16530
Phenotypes of a mutant
- essential PubMed
- the uppS86 (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin PubMed=== Database entries ===
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate
- Protein family: UPP synthetase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O31751
- KEGG entry: [2]
- E.C. number: 2.5.1.31
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Takashi Inaoka, Kozo Ochi
Undecaprenyl pyrophosphate involvement in susceptibility of Bacillus subtilis to rare earth elements.
J Bacteriol: 2012, 194(20);5632-7
[PubMed:22904278]
[WorldCat.org]
[DOI]
(I p)
