Difference between revisions of "GdpP"
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| − | + | * inactivation of ''[[gdpP]]'' strongly restores beta-lactam resistance in a ''[[sigM]]'' mutant {{PubMed|22211522}} | |
=== Database entries === | === Database entries === | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' cyclic dinucleotide phosphodiesterase, hydrolysis of di-cyclic AMP {{PubMed|19901023}} | + | * '''Catalyzed reaction/ biological activity:''' |
| + | ** cyclic dinucleotide phosphodiesterase, hydrolysis of di-cyclic AMP {{PubMed|19901023}} | ||
* '''Protein family:''' | * '''Protein family:''' | ||
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** Heme binding suppresses phosphodiesterase activity {{PubMed|21257773}} | ** Heme binding suppresses phosphodiesterase activity {{PubMed|21257773}} | ||
| − | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
| − | * '''Localization:''' | + | * '''[[Localization]]:''' |
=== Database entries === | === Database entries === | ||
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=References= | =References= | ||
'''Additional publications:''' {{PubMed|22211522}} | '''Additional publications:''' {{PubMed|22211522}} | ||
| − | <pubmed> 19901023 21257773 | + | <pubmed> 19901023 21257773 21566650</pubmed> |
==GdpP homologs in other organisms== | ==GdpP homologs in other organisms== | ||
<pubmed> 18502872 </pubmed> | <pubmed> 18502872 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 19:07, 21 July 2012
- Description: cyclic di-AMP phosphodiesterase
| Gene name | gdpP |
| Synonyms | yybT |
| Essential | no |
| Product | c-di-AMP phosphodiesterase |
| Function | control of sporulation initiation, cell wall homeostasis |
| MW, pI | 74 kDa, 4.865 |
| Gene length, protein length | 1977 bp, 659 aa |
| Immediate neighbours | rplI, yybS |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
metabolism of signalling nucleotides
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU40510
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- cyclic dinucleotide phosphodiesterase, hydrolysis of di-cyclic AMP PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- N-terminal domain that shares minimum sequence homology with Per-ARNT-Sim (PAS) domains PubMed
- Modification:
- Cofactor(s): b-type heme with 1:1 stoichiometry PubMed
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P37484
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
GdpP homologs in other organisms
