YcdA

Gene name	ycdA
Synonyms
Essential	no
Product	lipoprotein
Function	swarming motility
Gene expression levels in SubtiExpress: ycdA
MW, pI	39 kDa, 4.706
Gene length, protein length	1062 bp, 354 aa
Immediate neighbours	yccK, ycdB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

membrane proteins, motility and chemotaxis

This gene is a member of the following regulons

Abh regulon, AbrB regulon, DegU regulon

The gene

Basic information

• Locus tag: BSU02780

Phenotypes of a mutant

• reduced swarming motility PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • lipoprotein PubMed
  • membrane associated PubMed

Database entries

• Structure:

• UniProt: O34538

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ycdA PubMed

• Expression browser: ycdA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • Abh and AbrB: synergistic transcription repression PubMed
  • DegU-P: transcription activation PubMed
  • SwrA: modulation of DegU-P activity at the ycdA promoter PubMed

• Additional information:
  • The mRNA has a long 5' leader region. This may indicate RNA-based regulation PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Mitsuo Ogura, Kensuke Tsukahara
SwrA regulates assembly of Bacillus subtilis DegU via its interaction with N-terminal domain of DegU.
J Biochem: 2012, 151(6);643-55
[PubMed:22496484] [WorldCat.org] [DOI] (I p)

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [WorldCat.org] [DOI] (I p)

Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711] [WorldCat.org] [DOI] (I p)