Difference between revisions of "RecQ"
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Revision as of 09:12, 16 April 2012
- Description: ATP-dependent DNA helicase
| Gene name | recQ |
| Synonyms | recS, ypbC |
| Essential | no |
| Product | ATP-dependent DNA helicase |
| Function | replication reactivation pathway |
| MW, pI | 56 kDa, 6.228 |
| Gene length, protein length | 1488 bp, 496 aa |
| Immediate neighbours | ypbD, ypbB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
DNA repair/ recombination, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU23020
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: RecQ subfamily (according to Swiss-Prot)
- Paralogous protein(s): YocI
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P50729
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Kara A Bernstein, Serge Gangloff, Rodney Rothstein
The RecQ DNA helicases in DNA repair.
Annu Rev Genet: 2010, 44;393-417
[PubMed:21047263]
[WorldCat.org]
[DOI]
(I p)
Leonard Wu, Ian D Hickson
RecQ helicases and cellular responses to DNA damage.
Mutat Res: 2002, 509(1-2);35-47
[PubMed:12427530]
[WorldCat.org]
[DOI]
(P p)
Original Publications
François Lecointe, Céline Sérèna, Marion Velten, Audrey Costes, Stephen McGovern, Jean-Christophe Meile, Jeffrey Errington, S Dusko Ehrlich, Philippe Noirot, Patrice Polard
Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks.
EMBO J: 2007, 26(19);4239-51
[PubMed:17853894]
[WorldCat.org]
[DOI]
(P p)
