KatA

• Description: main vegetative catalase 1
  
  

Gene name	katA
Synonyms	kat-19
Essential	no
Product	vegetative catalase
Function	detoxification (degradation) of hydrogen peroxide
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	54 kDa, 6.151
Gene length, protein length	1449 bp, 483 aa
Immediate neighbours	senS, ssuB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

resistance against oxidative and electrophile stress

This gene is a member of the following regulons

PerR regulon

The gene

Basic information

• Locus tag: BSU08820

Phenotypes of a mutant

• increased sensitivity to oxidative stress PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2 H₂O₂ = O₂ + 2 H₂O (according to Swiss-Prot)

• Protein family: catalase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): contains an iron-sulfur cluster, heme

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 1SI8 (enzyme from Enterococcus faecalis, 68% identity)

• UniProt: P26901

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: katA PubMed

• Sigma factor:

• Regulation:
  • induced in the presence of hydrogen peroxide and paraquat (PerR) PubMed

• Regulatory mechanism:
  • PerR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: